Online Clinical Case Study (March 2009)

Clinical Cardiology Series
臨床心臟科個案研究

The content of the Office Cardiology Series is provided by:
Dr. TAM Chi Ming
MBBS (HK), MRCP (UK), FHKCP, FHKAM (Med), Specialist in Cardiology
Dr. LI Siu Lung, Steven
FHKAM (Med), FRCP (Glasg), FRCP (Edin), FRCP (Lond), Specialist in Cardiology
Dr. WONG Shou Pang, Alexander
FRCP, FHKAM (Med.), FHKCP, Specialist in Cardiology
臨床心臟科個案研究之內容誠蒙譚志明醫生、李少隆醫生及王壽鵬醫生提供。

A 61-year-old lady with sudden onset fast palpitations

A 61-year-old lady presented to the A&E department for sudden onset fast palpitations. She has been suffering from worsening effort intolerance with intermittent fast palpitations. There was no history of syncope. Figure 1 shows her ECG during palpitation.

Her arrhythmia was controlled with IV amiodarone and she was put on low-dose beta-blocker for maintenance therapy. Since then she has had no more fast palpitations, but experienced postural giddiness and worsening exertional shortness of breath. Her pulse rate remained at 40–50 while she was on a minimal dose of betablocker. The beta-blocker was thus stopped for 2 weeks and a treadmill test was performed (Figure 2).


Figure 1: ECG during palpitation.


Figure 2. Treadmill test.

Answers

1.

What is the diagnosis (Figure 1)?
a. Fast atrial fibrillation
b. Wolff Parkinson White syndrome (pre-excitation syndrome)
c. Atrial tachycardia
d. Sinus tachycardia

  a
   
2.

What is the diagnosis (Figure 2)?
a. Sick sinus syndrome with chronotropic incompetence
b. Pre-excitation with heart block
c. Normal treadmill test
d. Wyman's syndrome

 

a

   
3.

What would be your next treatment?
a. Change to another anti-arrhythmic
b. Electrophysiological study and radiofrequency ablation of the accessory pathway
c. Rate adaptive pacemaker
d. Coronary angiography and angioplasty

 

c

 

This lady suffers from sick sinus syndrome with tachyand brady-arrhythmia. Her tachy-arrhythmia manifests as paroxysmal atrial fibrillation while her brady-arrhythmia manifests as sinus bradycardia with chronotropic incompetence. Sick sinus syndrome sometimes causes a management dilemma as medical treatment is effective against tachy-arrhythmia but not brady-arrhythmia. Effective rate limiting drugs can further aggravate bradycardia while the patient’s sinus node fails to respond to rate demand. This patient has very sick sinus node pacemaker and her exercise capacity was limited by her slow heart rate (chronotropic incompetence). Her heart rate could barely rise to 100/min (65% target, normal >85%) to achieve a maximum workload of 5.8 METS. The patient subsequently received a rate adaptive dual chamber pacemaker. Her beta-blockade was thus increased to suppress her paroxysmal atrial fibrillation with the pacemaker as back-up. Anti-coagulation is indicated if subsequent Holter strips show high atrial fibrillation load (Figure 3).


Figure 3: Atrial pacing after pacemaker implantation.

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Dermatology Series 皮膚科病例研究

A 45-year-old lady with a rash on the ankle

A 45-year-old lady with previously good past health complained of a rash on her right ankle for few days. She sprained her right ankle around two weeks ago and was treated by a bone-setter with topical herbal medication for one week. She stopped the medication when the pain and swelling subsided. She then noticed an itchy red rash over the treatment site. Physical examination showed a well defined erythematous patch over the right ankle, associated with blisters formation.

The content of the Dermatology Series is provided by:
Dr. CHAN Hau-ngai, Kingsley, Dr. TANG Yuk-ming, William,
Dr. CHAN Loi-yuen & Dr. MAK Kam-har
Specialists in Dermatology & Venereology
皮膚科病例研究之內容誠蒙陳厚毅醫生、鄧旭明醫生、陳來源醫生及麥錦霞醫生提供。

Answers

1.

What are the diagnosis and differential diagnoses?

The patient is suffering from acute allergic contact dermatitis due to the bone-setter’s herbal medications (known as bone-setter’s herbs dermatitis). The differential diagnoses include acute irritant contact dermatitis, cellulitis, discoid eczema and herpes simplex infection.
 

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2.

What is the pathogenesis?

Allergic contact dermatitis is a cell-mediated type IV delayed hypersensitivity reaction resulting from specific antigens penetrating the epidermal skin layer. The antigen combines with a protein mediator and then travels to the dermis, where T lymphocytes become sensitized. On the subsequent exposure to the antigen, the allergic reaction will take place.
 

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3.

What are the factors that will affect the severity?

Duration of exposure and presence of a co-existing skin infection will affect the severity of allergic contact dermatitis.
 

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4.

What are the common causes for this type of skin disorder?

Myrrh (沒藥) is the most common cause of bone-setter’s herbs dermatitis. In Hong Kong, the most common cause of allergic contact dermatitis is nickel sulfate (metal alloys). Other common allergens include fragrance mixes, potassium dichromate (cements, household cleaners), formaldehyde (dyes, medications), mercaptobenzothiazole (rubbers), paraphenylenediamine (dyes, photographic chemicals) and plants.

 

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5.

What are the treatments?

The allergen should be identified and avoided. Topical steroids of medium-to-high strength are the mainstay treatment of most cases of allergic contact dermatitis. Systemic steroids are reserved for severe cases of allergic contact dermatitis with greater extent and bullae formation. The patient should be warned of recrudescence upon re-exposure to the offending allergen.
 

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